The work marks what should be the end of a project to widen the bridge that began January 2013.
The bridge closure will be complete, requiring traffic to use River Road, Esser Road and East Blanco Road as a detour. Local residents may recognize the detour as the same route used when Main Street closes for parades.
Each night, the closure will begin at 9 p.m. and crews will open the bridge in time for the morning commute.